GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2076028 | 1 | rs6519124 | chr22:39045099 | LOC646851 | chr22:38974125-39052634:- | 0.13 | 3.54 | 0.000435 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs6519124 | chr22:39045099 | TOMM22 | chr22:39077954-39080763:+ | -0.17 | -3.67 | 0.000267 | Resting heart rate |
| THCA | cis | rs2273 | 1 | rs6532078 | chr4:76920809 | NAAA | chr4:76831809-76862166:- | -0.33 | -6.54 | 1.61E-10 | Longevity |
| THCA | cis | rs10518128 | 1 | rs6532432 | chr4:75696811 | BTC | chr4:75671448-75719882:- | 0.2 | 3.77 | 0.000186 | Electroencephalogram traits |
| THCA | cis | rs4699052 | 1 | rs6533059 | chr4:104133376 | BDH2 | chr4:103998783-104021024:- | 0.26 | 6.04 | 3.18E-9 | Testicular germ cell tumor |
| THCA | cis | rs4699052 | 1 | rs6533059 | chr4:104133376 | CISD2 | chr4:103790135-103809913:+ | -0.15 | -3.42 | 0.000676 | Testicular germ cell tumor |
| THCA | cis | rs4699052 | 1 | rs6533059 | chr4:104133376 | MANBA | chr4:103552644-103682151:- | 0.16 | 4.05 | 6.04E-5 | Testicular germ cell tumor |
| THCA | cis | rs4699052 | 1 | rs6533060 | chr4:104139996 | BDH2 | chr4:103998783-104021024:- | 0.26 | 6.09 | 2.28E-9 | Testicular germ cell tumor |
| THCA | cis | rs4699052 | 1 | rs6533060 | chr4:104139996 | CISD2 | chr4:103790135-103809913:+ | -0.15 | -3.4 | 0.000737 | Testicular germ cell tumor |
| THCA | cis | rs4699052 | 1 | rs6533060 | chr4:104139996 | MANBA | chr4:103552644-103682151:- | 0.16 | 4.07 | 5.46E-5 | Testicular germ cell tumor |
| THCA | cis | rs685001 | 1 | rs653554 | chr1:48022641 | FOXD2 | chr1:47901689-47906362:+ | 0.23 | 4 | 7.21E-5 | Obesity-related traits |
| THCA | cis | rs685001 | 1 | rs653554 | chr1:48022641 | MGC12982 | chr1:47897808-47900313:- | 0.21 | 4.34 | 1.7E-5 | Obesity-related traits |
| THCA | cis | rs8396 | 1 | rs6536365 | chr4:159632293 | ETFDH | chr4:159593277-159629839:+ | 0.17 | 4.27 | 2.4E-5 | Blood metabolite levels;Metabolite levels;Metabolic traits;Acylcarnitine levels |
| THCA | cis | rs8396 | 1 | rs6536365 | chr4:159632293 | PPID | chr4:159630280-159644552:- | -0.26 | -4.92 | 1.18E-6 | Blood metabolite levels;Metabolite levels;Metabolic traits;Acylcarnitine levels |
| THCA | cis | rs4691139 | 1 | rs6536882 | chr4:165900680 | C4orf39 | chr4:165878100-165880273:+ | 0.2 | 5.54 | 5.14E-8 | Ovarian cancer in BRCA1 mutation carriers |